Curriculum Vitae

Sept. 2022 - Current:

McGill University – Montreal (Canada)

PhD Candidate, Integrated Program in Neuroscience – GPA 4.00

Sept. 2020 – June 2022

McGill University – Montreal (Canada)

M.Sc. program, Integrated Program in Neuroscience – GPA 4.00

Sept. 2016 – June 2020

McGill University – Montreal (Canada)

Bachelor of Science, Major in Honours Neuroscience - GPA 3.90

Do Carmo S, Kautzmann MI, Bhattacharjee S, Jun B, Steinberg C, Emmerson JT, Malcolm JC, Bonomo Q, Bazan NG, Cuello AC (2024). Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology. J Neuroinflammation. 21, 185.

- Performed immunofluorescence procedures and analyses.

Emmerson JT, Do Carmo S, Liu Y, Shalhoub A, Liu A, Bonomo Q, Malcolm JC, Breuillaud L, Martinez-Trujillo JC, Cuello AC (2023). Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model. Neurobiol. Dis. 184, 106227.

- Assisted with tissue preparation of Sarkosyl extracts and Electrochemiluminescence (ECLIA) procedures.

Orciani C, Do Carmo S, Foret MK, Hall H, Bonomo Q, Lavagna A, Huang C, Cuello AC (2023). Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology. Neurobiol. Aging 132, 220-232.

- Administered an experimental compound in rats.

2021 – 2022

McGill University

Teaching assistant – INDS 212: Human Behaviour

Provided hands-on expertise to medical school trainees over two semesters in performing human brain dissections.

2024

McGill University

Workshop – Course Design Essentials (supervised by Dr. Carolyn Samuel)

Sept. 2019 – Apr. 2020

McGill University – Dr. Sadikot & Dr. Kennedy’s Laboratories

Investigated the neuroprotective role of DCC Netrin 1 Receptor in mature dopamine neurons, with a focus on its involvement in Parkinson’s disease-related motor impairments.

- Performed stereotactic AAV2-retro viral injection in the dorsolateral striatum of floxed DCC mice to achieve local DCC knockdown in mouse nigrostriatal dopamine neurons.

- Tested knockdown efficiency using immunohistochemistry and Western blot analysis.

Sept. 2018 – Jul. 2019

McGill University – Dr. Sadikot’s Laboratory:

Conducted research to identify adeno-associated virus (AAV) serotype 6 as a potential viral vector for therapeutic gene delivery in Huntington’s disease.

- Performed stereotactic injections in the mouse parafascicular thalamic nucleus, transcardial perfusion, brain tissue processing, and immunohistochemistry.

- Validated AAV6's retrograde transport capability through tracing analysis.

Feb. 2017 – Apr. 2017

McGill University – Dr. Kmita’s Laboratory:

Assisted in a project studying the expression of Hox genes during embryogenesis and development in mice.

- Performed electroporation, polymerase chain reaction, agarose gel electrophoresis and in situ hybridization.

2015 – 2016

International School of Boston (Cambridge, MA, USA):

Teaching assistant

Assisted students with homework and reviewed academic content to increase student achievement.

“The McGill-R955-hTau transgenic rat model developing progressive human-like tauopathy”

- Invention ID# D2024-0057, McGill University Research and Innovation Department (Approved July 2023)

- A transgenic rat model designed as a platform to study tauopathies, including Alzheimer’s disease (AD) and frontotemporal dementias, while enabling biomarker discovery and the testing and validation of potential therapeutic interventions.